We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction.

Biroccio, A., Porru, M., Rizzo, A., Salvati, E., D'Angelo, C., Orlandi, A., et al. (2011). DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents. CLINICAL CANCER RESEARCH, 17(8), 2227-2236 [10.1158/1078-0432.CCR-10-3033].

DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents

ORLANDI, AUGUSTO;
2011-04-15

Abstract

We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The present study aims at investigating the mechanisms involved in this specific drug interaction.
15-apr-2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Con Impact Factor ISI
Animals; Topoisomerase I Inhibitors; Apoptosis; G-Quadruplexes; Telomere; DNA Damage; Humans; Mice, Nude; Mice; HCT116 Cells; Camptothecin; Cell Survival; Acridines; Cells, Cultured; Treatment Outcome; Antineoplastic Combined Chemotherapy Protocols; Xenograft Model Antitumor Assays; HT29 Cells; Drug Synergism; Cell Cycle; Colonic Neoplasms; Male
Biroccio, A., Porru, M., Rizzo, A., Salvati, E., D'Angelo, C., Orlandi, A., et al. (2011). DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents. CLINICAL CANCER RESEARCH, 17(8), 2227-2236 [10.1158/1078-0432.CCR-10-3033].
Biroccio, A; Porru, M; Rizzo, A; Salvati, E; D'Angelo, C; Orlandi, A; Passeri, D; Franceschin, M; Stevens, M; Gilson, E; Beretta, G; Zupi, G; Pisano, C; Zunino, F; Leonetti, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/53003
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