In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34+ cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34+ cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. © 2003 Elsevier Science B.V. All rights reserved.

Bracci-Laudiero, L., Celestino, D., Starace, G., Antonelli, A., Lambiase, A., Procoli, A., et al. (2003). CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA. JOURNAL OF NEUROIMMUNOLOGY, 136, 130-139 [10.1016/S0165-5728(03)00007-9].

CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA

PICARDI, ALESSANDRA;
2003

Abstract

In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34+ cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34+ cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. © 2003 Elsevier Science B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - Neurologia
English
Hematopoiesis; Human stem cells; Neurotrophins
Bracci-Laudiero, L., Celestino, D., Starace, G., Antonelli, A., Lambiase, A., Procoli, A., et al. (2003). CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA. JOURNAL OF NEUROIMMUNOLOGY, 136, 130-139 [10.1016/S0165-5728(03)00007-9].
Bracci Laudiero, L; Celestino, D; Starace, G; Antonelli, A; Lambiase, A; Procoli, A; Rumi, C; Lai, M; Picardi, A; Ballatore, G; Bonini, S; Aloe, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/52968
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