In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34+ cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34+ cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. © 2003 Elsevier Science B.V. All rights reserved.
Bracci Laudiero, L., Celestino, D., Starace, G., Antonelli, A., Lambiase, A., Procoli, A., et al. (2003). CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA. JOURNAL OF NEUROIMMUNOLOGY, 136, 130-139 [10.1016/S0165-5728(03)00007-9].
CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
PICARDI, ALESSANDRA;
2003-01-01
Abstract
In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34+ cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34+ cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. © 2003 Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
