A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast cancer patients and the NK boosting effect of human beta IFN. In vitro immunochemistry studies showed that marked antitumor effects were obtained against cultured cancer cells when a widely used chemotherapeutic agent such as 5-FU was combined with nonsensitized spontaneously cytolytic MNC, preactivated in vitro with beta IFN. These results suggest that the in vitro susceptibility assay of MNC to IFNs could be used for predicting favorable responses to immunochemotherapy regimens employing IFNs as immunomodulating agents.

D'Atri, S., Fuggetta, M., Giganti, M.g., Tentori, L., Roselli, M., Nunziata, C., et al. (1988). Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy. CANCER IMMUNOLOGY, IMMUNOTHERAPY, 27(2), 163-170.

Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy

GIGANTI, MARIA GABRIELLA;TENTORI, LUCIO;ROSELLI, MARIO;BONMASSAR, ENZO;DE VECCHIS, LIANA
1988-01-01

Abstract

A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast cancer patients and the NK boosting effect of human beta IFN. In vitro immunochemistry studies showed that marked antitumor effects were obtained against cultured cancer cells when a widely used chemotherapeutic agent such as 5-FU was combined with nonsensitized spontaneously cytolytic MNC, preactivated in vitro with beta IFN. These results suggest that the in vitro susceptibility assay of MNC to IFNs could be used for predicting favorable responses to immunochemotherapy regimens employing IFNs as immunomodulating agents.
1988
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Cytotoxicity, Immunologic; Neoplasms; Tumor Cells, Cultured; Killer Cells, Natural; Immunotherapy; Humans; Fluorouracil; Interferon Type I; Drug Synergism; Female
D'Atri, S., Fuggetta, M., Giganti, M.g., Tentori, L., Roselli, M., Nunziata, C., et al. (1988). Comparative studies between in vitro and in vivo effects of human beta-interferon on natural killer activity and its relevance to immunochemotherapy. CANCER IMMUNOLOGY, IMMUNOTHERAPY, 27(2), 163-170.
D'Atri, S; Fuggetta, M; Giganti, Mg; Tentori, L; Roselli, M; Nunziata, C; Pastore, S; Bonmassar, E; DE VECCHIS, L
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/52952
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