A new case of refractory anemia with excess of blasts (RAEB) with acquired Hemoglobin H disease (HbH) evolving into acute nonlymphoid leukemia (ANLL) is reported. In this patient, both family and personal history were negative for alpha thalassemia. At time of diagnosis of RAEB, 'golf ball' erythrocytic inclusions, typical of HbH, were found. The cellulose acetate electrophoresis (pH 8.9) revealed a fast moving band, corresponding to HbH. An evolution into ANLL, M1 subtype, 25 months later, has been documented.

Annino, L., Di Giovanni, S., Tentori, L., Cafolla, A., Nanni Costa, M., Salvagnini, M., et al. (1984). Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia. ACTA HAEMATOLOGICA, 72(1), 41-44.

Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia

TENTORI, LUCIO;
1984

Abstract

A new case of refractory anemia with excess of blasts (RAEB) with acquired Hemoglobin H disease (HbH) evolving into acute nonlymphoid leukemia (ANLL) is reported. In this patient, both family and personal history were negative for alpha thalassemia. At time of diagnosis of RAEB, 'golf ball' erythrocytic inclusions, typical of HbH, were found. The cellulose acetate electrophoresis (pH 8.9) revealed a fast moving band, corresponding to HbH. An evolution into ANLL, M1 subtype, 25 months later, has been documented.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Bone Marrow Cells; Leukemia; Hematopoietic Stem Cells; Humans; Anemia, Aplastic; Electrophoresis, Cellulose Acetate; Aged; Thalassemia; Male
Annino, L., Di Giovanni, S., Tentori, L., Cafolla, A., Nanni Costa, M., Salvagnini, M., et al. (1984). Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia. ACTA HAEMATOLOGICA, 72(1), 41-44.
Annino, L; Di Giovanni, S; Tentori, L; Cafolla, A; Nanni Costa, M; Salvagnini, M; Angeli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/52942
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