Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged.

Rotilio, G., Carri', M.t., Rossi, L., Ciriolo, M.r. (2000). Copper-dependent oxidative stress and neurodegeneration. IUBMB LIFE, 50(4-5), 309-314 [10.1080/713803724].

Copper-dependent oxidative stress and neurodegeneration

ROTILIO, GIUSEPPE;CARRI', MARIA TERESA;ROSSI, LUISA;CIRIOLO, MARIA ROSA
2000-01-01

Abstract

Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged.
2000
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
Superoxide Dismutase; Animals; Apoptosis; Hepatolenticular Degeneration; Humans; Alzheimer Disease; Copper; Neurodegenerative Diseases; Nerve Degeneration; Amyotrophic Lateral Sclerosis; Menkes Kinky Hair Syndrome; Oxidative Stress; Prion Diseases; Models, Neurological
Rotilio, G., Carri', M.t., Rossi, L., Ciriolo, M.r. (2000). Copper-dependent oxidative stress and neurodegeneration. IUBMB LIFE, 50(4-5), 309-314 [10.1080/713803724].
Rotilio, G; Carri', Mt; Rossi, L; Ciriolo, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/52694
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