Although suppression of apoptosis contributes to immune-reconstitution during potent antiretroviral therapy, its relationship with the majors indicators of response to therapy, that is, changes in CD4(+) cell counts and in viral loads (VL), is still debated. We extended our previous study by collecting data on the relationships among apoptosis and immunological and virological parameters during a long-term follow-up of HIV patients with an overall positive response to potent antiretroviral therapy. We report results from 15 patients who completed two years of therapy. In a smaller group of patients, we focused our attention on investigating the specific contribution of the CD8(+) subset in the overall changes in lymphocyte apoptosis, which occur concomitantly with the response to the therapy. Our data, while again confirming that inhibition of PBMC apoptosis is a phenomenon strictly related to a positive response to potent antiretroviral therapy, suggest that CD4(+) cell rescue is not directly dependent on inhibition of CD4(+) cell apoptosis but rather on that of the CD8(+) subset.

Grelli, S., D'Ettore, G., Lauria, F., Montella, F., Di Traglia, L., D'Agostini, C., et al. (2003). CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1010, 560-564 [10.1196/annals.1299.104].

CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis

GRELLI, SANDRO;FAVALLI, CARTESIO;MACCHI, BEATRICE;
2003

Abstract

Although suppression of apoptosis contributes to immune-reconstitution during potent antiretroviral therapy, its relationship with the majors indicators of response to therapy, that is, changes in CD4(+) cell counts and in viral loads (VL), is still debated. We extended our previous study by collecting data on the relationships among apoptosis and immunological and virological parameters during a long-term follow-up of HIV patients with an overall positive response to potent antiretroviral therapy. We report results from 15 patients who completed two years of therapy. In a smaller group of patients, we focused our attention on investigating the specific contribution of the CD8(+) subset in the overall changes in lymphocyte apoptosis, which occur concomitantly with the response to the therapy. Our data, while again confirming that inhibition of PBMC apoptosis is a phenomenon strictly related to a positive response to potent antiretroviral therapy, suggest that CD4(+) cell rescue is not directly dependent on inhibition of CD4(+) cell apoptosis but rather on that of the CD8(+) subset.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore BIO/14
English
Con Impact Factor ISI
Viral Load; Apoptosis; Anti-HIV Agents; HIV Infections; Humans; CD8-Positive T-Lymphocytes; CD4 Lymphocyte Count
Grelli, S., D'Ettore, G., Lauria, F., Montella, F., Di Traglia, L., D'Agostini, C., et al. (2003). CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1010, 560-564 [10.1196/annals.1299.104].
Grelli, S; D'Ettore, G; Lauria, F; Montella, F; Di Traglia, L; D'Agostini, C; Lichtner, M; Vullo, V; Favalli, C; Vella, S; Macchi, B; Mastino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/52445
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