Gabapentin, 3-sostituted of GABA, is a remarkably efficacious treatment for neuropathic pain in human and animal models. Although it has been sinthetized as a GABA analogue, gabapentin is not a GABA mimetic. Gabapentin interacts with alfa2delta subunit of Ca2+-channels voltage-dependents, but its intracellular activity and its analgesic action are unclear. This paper shows the Gabapentin treatment efficacy on post-herpetic pain on 17 patients. The dose of titrated Gabapentin has been 1200 mg/day to 3600 mg/day (max). There has been a significant decrease of pain during the 2th and the 4th month in "the toracic group", while during the second month, only, in the trigeminal group.

Gatti A., S.G. (2001). Treatment of post-herpetic neuralgia with gabapentin: Thoracic localization, 22(2), 35-38.

Treatment of post-herpetic neuralgia with gabapentin: Thoracic localization

GATTI, ANTONIO;
2001

Abstract

Gabapentin, 3-sostituted of GABA, is a remarkably efficacious treatment for neuropathic pain in human and animal models. Although it has been sinthetized as a GABA analogue, gabapentin is not a GABA mimetic. Gabapentin interacts with alfa2delta subunit of Ca2+-channels voltage-dependents, but its intracellular activity and its analgesic action are unclear. This paper shows the Gabapentin treatment efficacy on post-herpetic pain on 17 patients. The dose of titrated Gabapentin has been 1200 mg/day to 3600 mg/day (max). There has been a significant decrease of pain during the 2th and the 4th month in "the toracic group", while during the second month, only, in the trigeminal group.
Pubblicato
Rilevanza internazionale
Abstract
Sì, ma tipo non specificato
Settore MED/41 - Anestesiologia
eng
Analgesia; Gabapentin; Post-herpetic neuralgia
Gatti A., S.G. (2001). Treatment of post-herpetic neuralgia with gabapentin: Thoracic localization, 22(2), 35-38.
Gatti, A; Serafini, G; Pedicelli, E; De Angelis, V; Alonzi, N; Frisardi, F; Befani, F; Sorrenti, D; Siglioccolo, A; Petrone, E; Bernardo, M; Flaminio, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/52285
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