Ribosomal protein synthesis is regulated by controlling the fraction of mRNA associated with polysomes. It is known that this value changes in different developmental stages during Xenopus embryogenesis or, more generally, with changing cell growth conditions. We present here an analysis of the proportion of mRNA loaded on polysomes, carried out with probes for five different ribosomal proteins on several batches of Xenopus embryos obtained from different individuals. The results obtained indicate the existence of probe-dependent and individual differences, which reflect genetic variations in the cis- and trans-acting regulatory elements responsible for translational regulation. The fraction of ribosomal protein mRNA loaded onto polysomes can be used as an index of an individual's capacity for ribosome production.

Bagni C., M.P. (1992). Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis. MOLECULAR AND GENERAL GENETICS, 234(1), 60-64.

Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis

BAGNI, CLAUDIA;TERRENATO, LUCIANO;AMALDI, FRANCESCO
1992

Abstract

Ribosomal protein synthesis is regulated by controlling the fraction of mRNA associated with polysomes. It is known that this value changes in different developmental stages during Xenopus embryogenesis or, more generally, with changing cell growth conditions. We present here an analysis of the proportion of mRNA loaded on polysomes, carried out with probes for five different ribosomal proteins on several batches of Xenopus embryos obtained from different individuals. The results obtained indicate the existence of probe-dependent and individual differences, which reflect genetic variations in the cis- and trans-acting regulatory elements responsible for translational regulation. The fraction of ribosomal protein mRNA loaded onto polysomes can be used as an index of an individual's capacity for ribosome production.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13
English
Con Impact Factor ISI
Ribosomal proteins; Translational regulation; Xenopus development
Bagni C., M.P. (1992). Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis. MOLECULAR AND GENERAL GENETICS, 234(1), 60-64.
Bagni, C; Mariottini, P; Terrenato, L; Amaldi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/52189
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