Ribosomal protein synthesis is regulated by controlling the fraction of mRNA associated with polysomes. It is known that this value changes in different developmental stages during Xenopus embryogenesis or, more generally, with changing cell growth conditions. We present here an analysis of the proportion of mRNA loaded on polysomes, carried out with probes for five different ribosomal proteins on several batches of Xenopus embryos obtained from different individuals. The results obtained indicate the existence of probe-dependent and individual differences, which reflect genetic variations in the cis- and trans-acting regulatory elements responsible for translational regulation. The fraction of ribosomal protein mRNA loaded onto polysomes can be used as an index of an individual's capacity for ribosome production.
Bagni C., M.P. (1992). Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis. MOLECULAR AND GENERAL GENETICS, 234(1), 60-64.
Tipologia: | Articolo su rivista |
Citazione: | Bagni C., M.P. (1992). Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis. MOLECULAR AND GENERAL GENETICS, 234(1), 60-64. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/13 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1992 |
Titolo: | Individual variability in the translational regulation of ribosomal protein synthesis in Xenopus laevis |
Autori: | |
Autori: | Bagni C., Mariottini P., Terrenato L., Amaldi F. |
Appare nelle tipologie: | 01 - Articolo su rivista |