Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor (p140 trkA) on the M/M surface. Treatment of HIV-infected human M/M with anti-NGF Ab blocking the biological activity of NGF leads to a marked decrease of the expression of p140 trkA high-affinity receptor, a concomitant increased expression of p75(NTR) low-affinity receptor for NCF, and the occurrence of apoptotic death of M/M. Taken together, these findings suggest a role for NCF as an autocrine survival factor that rescues human M/M from the cytopathic effect caused by HIV infection.

Garaci E., C.M. (1999). Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 14013-14018 [10.1073/pnas.96.24.14013].

Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV

GARACI, ENRICO;PIACENTINI, MAURO;COSTA, NICOLO';PERNO, CARLO FEDERICO;
1999

Abstract

Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor (p140 trkA) on the M/M surface. Treatment of HIV-infected human M/M with anti-NGF Ab blocking the biological activity of NGF leads to a marked decrease of the expression of p140 trkA high-affinity receptor, a concomitant increased expression of p75(NTR) low-affinity receptor for NCF, and the occurrence of apoptotic death of M/M. Taken together, these findings suggest a role for NCF as an autocrine survival factor that rescues human M/M from the cytopathic effect caused by HIV infection.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
nerve growth factor; neurotrophin; affinity chromatography; article; autocrine effect; cell survival; cytopathogenic effect; gene expression; genome; human; human cell; human immunodeficiency virus; human immunodeficiency virus infection; pathogenesis; phagocytosis; priority journal; receptor binding; survival; Animals; Apoptosis; Cell Survival; Cells, Cultured; HIV-1; Humans; Macrophages; Nerve Growth Factor; Rabbits; Receptor, Nerve Growth Factor; Receptor, trkA; Human immunodeficiency virus; RNA viruses
Garaci E., C.M. (1999). Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 14013-14018 [10.1073/pnas.96.24.14013].
Garaci, E; Caroleo, Mc; Aloe, L; Aquaro, S; Piacentini, M; Costa, N; Amendola, A; Micera, A; Calio, R; Perno, Cf; Levi Montalcini, R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/52009
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