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EnglishNerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor (p140 trkA) on the M/M surface. Treatment of HIV-infected human M/M with anti-NGF Ab blocking the biological activity of NGF leads to a marked decrease of the expression of p140 trkA high-affinity receptor, a concomitant increased expression of p75(NTR) low-affinity receptor for NCF, and the occurrence of apoptotic death of M/M. Taken together, these findings suggest a role for NCF as an autocrine survival factor that rescues human M/M from the cytopathic effect caused by HIV infection.
Garaci E., C.M. (1999). Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 14013-14018.
| Tipologia: | Articolo su rivista | |
| Citazione: | Garaci E., C.M. (1999). Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(24), 14013-14018. | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica | |
| Revisione (peer review): | Sì, ma tipo non specificato | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1073/pnas.96.24.14013 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 1999 | |
| Titolo: | Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV | |
| Autori: | ||
| Autori: | Garaci E., Caroleo M.C., Aloe L., Aquaro S., Piacentini M., Costa N., Amendola A., Micera A., Calio R., Perno C.-F., Levi-Montalcini R. | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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