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EnglishThe sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein, followed by caspase activation, and apoptotic death of CESS cells. Bcl-2 phosphorylation in several sites within a approximate to 60 aa "loop" domain of protein is known to regulate its antiapoptotic function. Accordingly, CESS cells expressing the loop deletional mutant cDNA constructs Bcl-2 Delta 40-91 were completely resistant to apoptosis induced by NGF withdrawal, indicating that Bcl-2 phosphorylation is a critical event. NGF withdrawal induces p38 MAPK, but not JNK, activation in CESS cells, and SB203580, a specific inhibitor of p38 MAPK, is able to prevent both Bcl-2 phosphorylation and apoptosis, indicating that p38 MAPK is the enzyme responsible for these events. (C) 2000 Academic Press.
| Tipologia: | Articolo su rivista |
| Citazione: | Rosini P., D.C.G. (2000). NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 278(3), 753-759. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Abstract |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1006/bbrc.2000.3871 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2000 |
| Titolo: | NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation |
| Autori: | |
| Autori: | Rosini P., De Chiara G., Lucibello M., Garaci E., Cozzolino F., Torcia M. |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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