Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.

Garaci, E., Palamara, A., Di Francesco, P., Favalli, C., Ciriolo, M., Rotilio, G. (1992). Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188(3), 1090-1096 [10.1016/0006-291X(92)91343-O].

Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus

GARACI, ENRICO;FAVALLI, CARTESIO;Ciriolo, MR;ROTILIO, GIUSEPPE
1992-01-01

Abstract

Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
glutathione; hemagglutinin; sialidase; virus glycoprotein; virus protein; animal cell; antiviral activity; article; cell level; cell metabolism; enzyme inactivation; host cell; kidney cell culture; monkey; monolayer culture; nonhuman; priority journal; sendai virus; virus expression; virus infection; virus inhibition; virus replication; Animal; Cells, Cultured; DNA, Viral; Glutathione; Parainfluenza Virus 1, Human; RNA, Viral; Support, Non-U.S. Gov't; Viral Proteins; Virus Replication; Animalia; Cercopithecus aethiops; Sendai virus
Garaci, E., Palamara, A., Di Francesco, P., Favalli, C., Ciriolo, M., Rotilio, G. (1992). Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188(3), 1090-1096 [10.1016/0006-291X(92)91343-O].
Garaci, E; Palamara, A; Di Francesco, P; Favalli, C; Ciriolo, M; Rotilio, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51967
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