Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
Garaci, E., Palamara, A., Di Francesco, P., Favalli, C., Ciriolo, M., Rotilio, G. (1992). Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188(3), 1090-1096 [10.1016/0006-291X(92)91343-O].
Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus
GARACI, ENRICO;FAVALLI, CARTESIO;Ciriolo, MR;ROTILIO, GIUSEPPE
1992-01-01
Abstract
Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
