Using intracerebral microdialysis in urethane-anaesthetized adult male Wistar rats, we monitored the effects of acute repetitive transcranial magnetic stimulation (rTMS; 20 trains of 20 Hz, 2.5 s) on the intrahypothalamic release of arginine vasopressin (AVP) and selected amino acids (glutamate, glutamine, aspartate, serine, arginine, taurine, γ-aminobutyric acid) and the intrahippocampal release of monoamines (dopamine, noradrenaline, serotonin) and their metabolites (homovanillic acid, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindoleacetic acid). The stimulation parameters were adjusted according to the results of accurate computer reconstructions of the current density distributions induced by rTMS in the rat and human brains, ensuring similar stimulation patterns in both cases. There was a continuous reduction in AVP release of up to 50% within the hypothalamic paraventricular nucleus in response to rTMS. In contrast, the release of taurine, aspartate and serine was selectively stimulated within this nucleus by rTMS. Furthermore, in the dorsal hippocampus the extracellular concentration of dopamine was elevated in response to rTMS. Taken together, these data provide the first in vivo evidence that acute rTMS of frontal brain regions has a differentiated modulatory effect on selected neurotransmitter/neuromodulator systems in distinct brain areas.

Keck, M., Sillaber, I., Ebner, K., Welt, T., Toschi, N., Kaehler, S., et al. (2000). Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. EUROPEAN JOURNAL OF NEUROSCIENCE, 12(10), 3713-3720 [10.1046/j.1460-9568.2000.00243.x].

Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain

TOSCHI, NICOLA;
2000-01-01

Abstract

Using intracerebral microdialysis in urethane-anaesthetized adult male Wistar rats, we monitored the effects of acute repetitive transcranial magnetic stimulation (rTMS; 20 trains of 20 Hz, 2.5 s) on the intrahypothalamic release of arginine vasopressin (AVP) and selected amino acids (glutamate, glutamine, aspartate, serine, arginine, taurine, γ-aminobutyric acid) and the intrahippocampal release of monoamines (dopamine, noradrenaline, serotonin) and their metabolites (homovanillic acid, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindoleacetic acid). The stimulation parameters were adjusted according to the results of accurate computer reconstructions of the current density distributions induced by rTMS in the rat and human brains, ensuring similar stimulation patterns in both cases. There was a continuous reduction in AVP release of up to 50% within the hypothalamic paraventricular nucleus in response to rTMS. In contrast, the release of taurine, aspartate and serine was selectively stimulated within this nucleus by rTMS. Furthermore, in the dorsal hippocampus the extracellular concentration of dopamine was elevated in response to rTMS. Taken together, these data provide the first in vivo evidence that acute rTMS of frontal brain regions has a differentiated modulatory effect on selected neurotransmitter/neuromodulator systems in distinct brain areas.
2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA)
Settore MED/26 - NEUROLOGIA
Settore MED/25 - PSICHIATRIA
English
Con Impact Factor ISI
3,4 dihydroxyphenylacetic acid; 4 aminobutyric acid; 5 hydroxyindoleacetic acid; amino acid derivative; arginine; aspartic acid; biogenic amine; dopamine; glutamic acid; glutamine; homovanillic acid; noradrenalin; serine; serotonin; taurine; vasopressin, amino acid brain level; animal experiment; animal tissue; article; brain depth stimulation; brain region; dopamine brain level; frontal cortex; human; hypothalamus; male; neuromodulation; nonhuman; priority journal; rat; thalamus midline nucleus; transcranial magnetic stimulation; vasopressin release, Amino Acids; Animals; Arginine Vasopressin; Biogenic Monoamines; Electric Stimulation; Electric Stimulation Therapy; Hippocampus; Humans; Hypothalamus; Male; Models, Neurological; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Transcranial Magnetic Stimulation; Vasopressins
Keck, M., Sillaber, I., Ebner, K., Welt, T., Toschi, N., Kaehler, S., et al. (2000). Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. EUROPEAN JOURNAL OF NEUROSCIENCE, 12(10), 3713-3720 [10.1046/j.1460-9568.2000.00243.x].
Keck, M; Sillaber, I; Ebner, K; Welt, T; Toschi, N; Kaehler, S; Singewald, N; Philippu, A; Elbel, G; Wotjak, C; Holsboer, F; Landgraf, R; Engelmann, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51846
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