The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC(50) twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly bi: correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.

Bergamaschi, S., Binetti, G., Govoni, S., Wetsel, W.c., Battaini, F.m., Trabucchi, M.m., et al. (1995). Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. NEUROSCIENCE LETTERS, 201(1), 1-4 [10.1016/0304-3940(95)12168-4].

Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO;
1995-01-01

Abstract

The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC(50) twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly bi: correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.
1995
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Alzheimer's disease; Amyloid precursor protein; Human skin fibroblasts; Phorbol esters; Protein kinase C
Bergamaschi, S., Binetti, G., Govoni, S., Wetsel, W.c., Battaini, F.m., Trabucchi, M.m., et al. (1995). Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts. NEUROSCIENCE LETTERS, 201(1), 1-4 [10.1016/0304-3940(95)12168-4].
Bergamaschi, S; Binetti, G; Govoni, S; Wetsel, Wc; Battaini, Fm; Trabucchi, Mm; Bianchetti, A; Racchi, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51571
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