Intracellular Ca2+ release channels are key players in the regulation of Ca2+ homeostasis. In the present study, we investigated the age-related changes of inositol 1,4,5-trisphosphate (IP3) receptor\Ca2+ release channel and ryanodine receptor\Ca2+ release channel in microsomes derived from either cerebellum or cerebrum cortex from male Wistar rats. A significant reduction (about 50%) in density of IP3 receptor\Ca2+ release channels was observed in cerebrum cortex, only, in 8- and 28-month old rats, whereas density and K-d of ryanodine binding sites were unaffected in both cerebellum and cerebrum microsomes. These findings, along with impairment of Ca2+-dependent protein kinase C phosphorylation of endogeneous substrates, point to coordinate, quantitative alterations of both targets of phosphoinasitide metabolism, i.e., PKC and IP3 receptor, in the cerebrum cortex at least. The relevance of the present findings is discussed in relation to reported changes of neuronal Ca2+ homeostasis during aging.

Martini, A., Battaini, F.m., Govoni, S., Volpe, P. (1994). INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR AND RYANODINE RECEPTOR IN THE AGING BRAIN OF WISTAR RATS. NEUROBIOLOGY OF AGING, 15(2), 203-206.

INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR AND RYANODINE RECEPTOR IN THE AGING BRAIN OF WISTAR RATS

BATTAINI, FIORENZO MARIA;VOLPE, PIETRO
1994-01-01

Abstract

Intracellular Ca2+ release channels are key players in the regulation of Ca2+ homeostasis. In the present study, we investigated the age-related changes of inositol 1,4,5-trisphosphate (IP3) receptor\Ca2+ release channel and ryanodine receptor\Ca2+ release channel in microsomes derived from either cerebellum or cerebrum cortex from male Wistar rats. A significant reduction (about 50%) in density of IP3 receptor\Ca2+ release channels was observed in cerebrum cortex, only, in 8- and 28-month old rats, whereas density and K-d of ryanodine binding sites were unaffected in both cerebellum and cerebrum microsomes. These findings, along with impairment of Ca2+-dependent protein kinase C phosphorylation of endogeneous substrates, point to coordinate, quantitative alterations of both targets of phosphoinasitide metabolism, i.e., PKC and IP3 receptor, in the cerebrum cortex at least. The relevance of the present findings is discussed in relation to reported changes of neuronal Ca2+ homeostasis during aging.
1994
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
AGING; WISTAR RAT; CA2+; CA2+ HOMEOSTASIS; CA2+ CHANNEL
4
Martini, A., Battaini, F.m., Govoni, S., Volpe, P. (1994). INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR AND RYANODINE RECEPTOR IN THE AGING BRAIN OF WISTAR RATS. NEUROBIOLOGY OF AGING, 15(2), 203-206.
Martini, A; Battaini, Fm; Govoni, S; Volpe, P
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51568
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