Drugs belonging to different chemical classes having the ability to improve behavioral performance in animal learning and memory tests may share the common ability to stimulate protein kinase C activity in rat brain cortex. In vitro acetyl-L-carnitine (100 nM) promoted in rat brain cortex slices a significant increase in particulate activity associated with lower soluble protein kinase C activity and produced a direct stimulation of the enzyme in both the cortex and hippocampus. In vivo a significant increase in particulate protein kinase C activity was observed in the group of rats treated with 60 mg/kg acetyl-L-carnitine, a dose shown to be effective in improving the cognitive deficits induced by scopolamine in the Morris maze test. The results suggest that acetyl-L-carnitine increases particulate protein kinase C activity in the cortex both in vitro and in vivo. This effect in the in vivo experiments seems to be observed only with doses that are effective in improving the performance of rats in a spatial learning task.

Pascale, A., Milano, S., Corsico, N., Lucchi, L., Battaini, F.m., Martelli, E., et al. (1994). Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies. EUROPEAN JOURNAL OF PHARMACOLOGY, 265(1-2), 1-7.

Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO;
1994-11-14

Abstract

Drugs belonging to different chemical classes having the ability to improve behavioral performance in animal learning and memory tests may share the common ability to stimulate protein kinase C activity in rat brain cortex. In vitro acetyl-L-carnitine (100 nM) promoted in rat brain cortex slices a significant increase in particulate activity associated with lower soluble protein kinase C activity and produced a direct stimulation of the enzyme in both the cortex and hippocampus. In vivo a significant increase in particulate protein kinase C activity was observed in the group of rats treated with 60 mg/kg acetyl-L-carnitine, a dose shown to be effective in improving the cognitive deficits induced by scopolamine in the Morris maze test. The results suggest that acetyl-L-carnitine increases particulate protein kinase C activity in the cortex both in vitro and in vivo. This effect in the in vivo experiments seems to be observed only with doses that are effective in improving the performance of rats in a spatial learning task.
14-nov-1994
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Hippocampus; Male; Protein Kinase C; Maze Learning; Cognition Disorders; Acetylcarnitine; Rats, Wistar; Rats; Amnesia; Dose-Response Relationship, Drug; Scopolamine; Animals; Down-Regulation; Cerebral Cortex; Enzyme Activation; Injections, Subcutaneous; Memory
Pascale, A., Milano, S., Corsico, N., Lucchi, L., Battaini, F.m., Martelli, E., et al. (1994). Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: in vitro and in vivo studies. EUROPEAN JOURNAL OF PHARMACOLOGY, 265(1-2), 1-7.
Pascale, A; Milano, S; Corsico, N; Lucchi, L; Battaini, Fm; Martelli, E; Trabucchi, Mm; Govoni, S
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51559
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 36
  • ???jsp.display-item.citation.isi??? ND
social impact