Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum.

Calabresi, P., Centonze, D., Gubellini, P., Pisani, A., Bernardi, G. (2000). Acetylcholine-mediated modulation of striatal function. TRENDS IN NEUROSCIENCES, 23(3), 120-126 [10.1016/S0166-2236(99)01501-5].

Acetylcholine-mediated modulation of striatal function

CALABRESI, PAOLO;CENTONZE, DIEGO;PISANI, ANTONIO;BERNARDI, GIORGIO
2000-03-01

Abstract

Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Acetylcholine; Corpus Striatum; Cells, Cultured; Nerve Net; Receptors, Muscarinic; Rats; Animals; Interneurons; N-Methylaspartate; Humans; Excitatory Amino Acids; Long-Term Potentiation; gamma-Aminobutyric Acid; Synaptic Transmission
Calabresi, P., Centonze, D., Gubellini, P., Pisani, A., Bernardi, G. (2000). Acetylcholine-mediated modulation of striatal function. TRENDS IN NEUROSCIENCES, 23(3), 120-126 [10.1016/S0166-2236(99)01501-5].
Calabresi, P; Centonze, D; Gubellini, P; Pisani, A; Bernardi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51498
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