Background: Asthma is an airway disorder characterized by bronchial inflammation. An imbalance between the oxidative forces and the antioxidant defense systems has been implicated in the pathogenesis of asthma. Glutathione S-transferases (GSTs) play an important role in cellular protection against inflammation. Several studies have investigated the genetic variability of GSTM1, GSTP1 and GSTT1 enzymes in asthma development with conflicting results. Moreover, in our previous independent case-control study on GSTs and asthma, we have found that GSTA1and GSTO2 gene polymorphisms are associated with asthma. The aim of the present study is to analyze if some functional polymorphisms of GSTA1, GSTM1, GSTP1, GSTO2 and GSTT1are associated with asthma in pediatric patients from Chieti (Italy). Methods: In this study, we performed an association study on 127 asthmatic children and 126 controls. We screened single nucleotide polymorphisms at GSTA1, GSTO2 and GSTP1loci. The effects of GSTM1and GSTT1nullgenotype were also investigated. Results: The GSTA1*-69Tand GSTO2*D142 variants are associated with the significant increased risk of asthma development in our study population, while GSTM1, GSTP1and GSTT1 genotype distributions were nearly equal between the control group and asthmatics. Conclusions: Confirming our previous study, these findings suggest that the GSTA1and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population.

Piacentini, S., Verrotti, A., Polimanti, R., Giannini, C., Saccucci, P., Manfellotto, D., et al. (2011). Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 50(2), 311-315 [10.1515/CCLM.2011.774].

Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children

SACCUCCI, PATRIZIA;FUCIARELLI, MARIA FELICITA
2011-10-31

Abstract

Background: Asthma is an airway disorder characterized by bronchial inflammation. An imbalance between the oxidative forces and the antioxidant defense systems has been implicated in the pathogenesis of asthma. Glutathione S-transferases (GSTs) play an important role in cellular protection against inflammation. Several studies have investigated the genetic variability of GSTM1, GSTP1 and GSTT1 enzymes in asthma development with conflicting results. Moreover, in our previous independent case-control study on GSTs and asthma, we have found that GSTA1and GSTO2 gene polymorphisms are associated with asthma. The aim of the present study is to analyze if some functional polymorphisms of GSTA1, GSTM1, GSTP1, GSTO2 and GSTT1are associated with asthma in pediatric patients from Chieti (Italy). Methods: In this study, we performed an association study on 127 asthmatic children and 126 controls. We screened single nucleotide polymorphisms at GSTA1, GSTO2 and GSTP1loci. The effects of GSTM1and GSTT1nullgenotype were also investigated. Results: The GSTA1*-69Tand GSTO2*D142 variants are associated with the significant increased risk of asthma development in our study population, while GSTM1, GSTP1and GSTT1 genotype distributions were nearly equal between the control group and asthmatics. Conclusions: Confirming our previous study, these findings suggest that the GSTA1and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population.
31-ott-2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/01 - STATISTICA MEDICA
English
Con Impact Factor ISI
Piacentini, S., Verrotti, A., Polimanti, R., Giannini, C., Saccucci, P., Manfellotto, D., et al. (2011). Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 50(2), 311-315 [10.1515/CCLM.2011.774].
Piacentini, S; Verrotti, A; Polimanti, R; Giannini, C; Saccucci, P; Manfellotto, D; Fuciarelli, Mf
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51490
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 19
social impact