We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of M1-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity.
Calabresi, P., Centonze, D., Gubellini, P., Bernardi, G. (1999). Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP. NEUROPHARMACOLOGY, 38(2), 323-326 [10.1016/S0028-3908(98)00199-3].
Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
CALABRESI, PAOLO;CENTONZE, DIEGO;BERNARDI, GIORGIO
1999-02-01
Abstract
We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of M1-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity.File in questo prodotto:
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