The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M(1)AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did not influence the lipid composition. There was a significant 2-fold increase of efficacy and 6-fold decrease of potency of carbachol-induced inositol phosphate (IF) accumulation in HO, with respect to control rats. The efficacy of trans-(1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD)-induced IP accumulation was also higher in HO (by 50%), without differences in EC50 values. The activities of soluble calcium-dependent and calcium-independent PKC were higher in HO than in control rats (both roughly 30%); membrane-associated PKCs were not modified. The data indicate that HO induces an increased responsiveness of M(1)AChRs and mGluRs and a rise in the soluble PKC activity that could be available and ready for translocation.

Pintor, A., Fortuna, S., Lorenzini, P., Pascale, A., Battaini, F.m., Avellino, C., et al. (1996). Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats. NEUROCHEMICAL RESEARCH, 21(5), 541-545.

Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats

BATTAINI, FIORENZO MARIA;
1996-01-01

Abstract

The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M(1)AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did not influence the lipid composition. There was a significant 2-fold increase of efficacy and 6-fold decrease of potency of carbachol-induced inositol phosphate (IF) accumulation in HO, with respect to control rats. The efficacy of trans-(1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD)-induced IP accumulation was also higher in HO (by 50%), without differences in EC50 values. The activities of soluble calcium-dependent and calcium-independent PKC were higher in HO than in control rats (both roughly 30%); membrane-associated PKCs were not modified. The data indicate that HO induces an increased responsiveness of M(1)AChRs and mGluRs and a rise in the soluble PKC activity that could be available and ready for translocation.
1996
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Inositolphosphate accumulation; M1-muscarinic receptors; Metabotropic glutamate receptors; Phospholipid composition; Protein kinase C; Rat brain
Pintor, A., Fortuna, S., Lorenzini, P., Pascale, A., Battaini, F.m., Avellino, C., et al. (1996). Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats. NEUROCHEMICAL RESEARCH, 21(5), 541-545.
Pintor, A; Fortuna, S; Lorenzini, P; Pascale, A; Battaini, Fm; Avellino, C; Malvezzi Campeggi, L; Salvati, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51478
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