We have characterized the specific binding of [3H]-phorbol-12,13-dibutyrate in the white and gray matter of normal human brain and in cerebral tumors as an index of the availability of protein kinase C enzyme molecules. White matter has less than 50% phorbol-ester-binding capacity in comparison to gray matter. The binding is lower in tumors of glial origin when compared with normal white matter. Tumors of nonglial origin such as neurinoma and meningioma have a lower binding capacity than glial tumors. Metastatic tissues have the lowest binding capacity. The analysis of binding parameters in tumors and in the corresponding normal peritumoral tissues confirms the decreased binding capacity of neoplastic tissues in comparison to tissues not undergoing malignant transformation. These data suggest that brain glial tumors have a low availability of protein kinase C enzyme molecules and point to the potential involvement of this system in malignant transformation of human brain cells.

Battaini, F.m., Leggio, A., Govoni, S., Frattola, L., Appollonio, I., Ferrarese, C., et al. (1990). Decrease in phorbol ester receptors in human brain tumors. EUROPEAN NEUROLOGY, 30(5), 241-246.

Decrease in phorbol ester receptors in human brain tumors

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1990-01-01

Abstract

We have characterized the specific binding of [3H]-phorbol-12,13-dibutyrate in the white and gray matter of normal human brain and in cerebral tumors as an index of the availability of protein kinase C enzyme molecules. White matter has less than 50% phorbol-ester-binding capacity in comparison to gray matter. The binding is lower in tumors of glial origin when compared with normal white matter. Tumors of nonglial origin such as neurinoma and meningioma have a lower binding capacity than glial tumors. Metastatic tissues have the lowest binding capacity. The analysis of binding parameters in tumors and in the corresponding normal peritumoral tissues confirms the decreased binding capacity of neoplastic tissues in comparison to tissues not undergoing malignant transformation. These data suggest that brain glial tumors have a low availability of protein kinase C enzyme molecules and point to the potential involvement of this system in malignant transformation of human brain cells.
1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Protein Kinase C; Neuroma, Acoustic; Middle Aged; Caenorhabditis elegans Proteins; Female; Radioligand Assay; Brain Neoplasms; Cerebral Cortex; Glioblastoma; Lung Neoplasms; Humans; Cell Transformation, Neoplastic; Signal Transduction; Receptors, Drug; Meningeal Neoplasms; Aged; Cell Division; Astrocytoma; Brain; Adult; Meningioma
Battaini, F.m., Leggio, A., Govoni, S., Frattola, L., Appollonio, I., Ferrarese, C., et al. (1990). Decrease in phorbol ester receptors in human brain tumors. EUROPEAN NEUROLOGY, 30(5), 241-246.
Battaini, Fm; Leggio, A; Govoni, S; Frattola, L; Appollonio, I; Ferrarese, C; Piolti, R; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51477
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