Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.

Moresco, R., Govoni, S., Battaini, F.m., Trivulzio, S., Trabucchi, M.m. (1990). Omegaconotoxin binding decreases in aged rat brain. NEUROBIOLOGY OF AGING, 11(4), 433-436.

Omegaconotoxin binding decreases in aged rat brain

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1990-01-01

Abstract

Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Hippocampus; Corpus Striatum; Male; omega-Conotoxins; Calcium Channels; Rats; Animals; Binding Sites; Cerebral Cortex; Age Factors; Peptides, Cyclic; Rats, Inbred Strains; Brain; Aging
Moresco, R., Govoni, S., Battaini, F.m., Trivulzio, S., Trabucchi, M.m. (1990). Omegaconotoxin binding decreases in aged rat brain. NEUROBIOLOGY OF AGING, 11(4), 433-436.
Moresco, R; Govoni, S; Battaini, Fm; Trivulzio, S; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51473
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