Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.

Govoni, S., Goss, I., Di Giovine, S., Battaini, F.m., Trabucchi, M.m. (1990). Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments. JOURNAL OF NEURAL TRANSMISSION, 80(1), 1-8.

Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1990-01-01

Abstract

Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.
1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Nimodipine; Male; Corpus Striatum; Calcium Channel Blockers; Enkephalin, Methionine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Rats, Inbred Strains; Rats; Animals
Govoni, S., Goss, I., Di Giovine, S., Battaini, F.m., Trabucchi, M.m. (1990). Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments. JOURNAL OF NEURAL TRANSMISSION, 80(1), 1-8.
Govoni, S; Goss, I; Di Giovine, S; Battaini, Fm; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51471
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