Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors.
Pascale A., B.F. (1997). Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats. ALCOHOL, 14(6), 557-561.
Tipologia: | Articolo su rivista | |
Citazione: | Pascale A., B.F. (1997). Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats. ALCOHOL, 14(6), 557-561. | |
IF: | Con Impact Factor ISI | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore BIO/14 | |
Revisione (peer review): | Sì, ma tipo non specificato | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0741-8329(97)00047-5 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 1997 | |
Titolo: | Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats | |
Autori: | ||
Autori: | Pascale A., Battaini F., Govoni S., Persichella M., De Salvia M.A., Cuomo V. | |
Appare nelle tipologie: | 01 - Articolo su rivista |