Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors.

Pascale, A., Battaini, F.m., Govoni, S., Persichella, M., De Salvia, M.a., Cuomo, V. (1997). Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats. ALCOHOL, 14(6), 557-561 [10.1016/S0741-8329(97)00047-5].

Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats

BATTAINI, FIORENZO MARIA;
1997-01-01

Abstract

Few studies have investigated neurobehavioral and neurochemical consequences of chronic consumption of low doses of ethanol. The present study shows that in rats exposure to 3% ethanol (v/v in drinking water) for 2 months decreased both calcium-dependent and independent protein kinase C (PKC) activities in the cortex and in the hippocampus. This treatment also reduced ultrasonic calls (UCs), an index of emotional and motivational states of the animal. In addition, at cortical level of ethanol-treated rats, we observed a correlation between calcium-dependent activities and UCs. These results suggest that nonaddicting doses of ethanol affect brain PKC activities and that this enzyme may be involved in the ethanol modulation of emotional and motivational behaviors.
1997
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Calcium dependent; Calcium independent; Cortex Hippocampus; Moderate ethanol; Protein kinase C; Rat; Vocalization
Pascale, A., Battaini, F.m., Govoni, S., Persichella, M., De Salvia, M.a., Cuomo, V. (1997). Chronic low doses of ethanol affect brain protein kinase C and ultrasonic calls in rats. ALCOHOL, 14(6), 557-561 [10.1016/S0741-8329(97)00047-5].
Pascale, A; Battaini, Fm; Govoni, S; Persichella, M; De Salvia, Ma; Cuomo, V
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51457
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