Protein kinase C (PKC) function was analyzed in aged male Sprague-Dawley rat brain using two different approaches: the binding of [3H]-phorbol-12,13-dibutyrate and the in vitro phosphorylation of histone H1. In cortex the binding was decreased while in cerebellum no age-related modifications were observed. In hippocampus the binding capacity was increased in old animals and the affinity decreased. The kinase activity in both soluble and particulate fractions was decreased in cortex, increased in hippocampus and unmodified in cerebellum. The area selective, age-dependent modifications in neuronal PKC may sustain short- and long-term regional changes of neuronal excitability.

Battaini, F.m., Del Vesco, R., Govoni, S., Trabucchi, M.m. (1990). Regulation of phorbol ester binding and protein kinase C activity in aged rat brain. NEUROBIOLOGY OF AGING, 11(5), 563-566.

Regulation of phorbol ester binding and protein kinase C activity in aged rat brain

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1990-01-01

Abstract

Protein kinase C (PKC) function was analyzed in aged male Sprague-Dawley rat brain using two different approaches: the binding of [3H]-phorbol-12,13-dibutyrate and the in vitro phosphorylation of histone H1. In cortex the binding was decreased while in cerebellum no age-related modifications were observed. In hippocampus the binding capacity was increased in old animals and the affinity decreased. The kinase activity in both soluble and particulate fractions was decreased in cortex, increased in hippocampus and unmodified in cerebellum. The area selective, age-dependent modifications in neuronal PKC may sustain short- and long-term regional changes of neuronal excitability.
1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Male; Age Factors; Protein Kinase C; Phorbol Esters; Rats, Inbred Strains; Rats; Brain; Animals; Binding Sites; Aging
Battaini, F.m., Del Vesco, R., Govoni, S., Trabucchi, M.m. (1990). Regulation of phorbol ester binding and protein kinase C activity in aged rat brain. NEUROBIOLOGY OF AGING, 11(5), 563-566.
Battaini, Fm; Del Vesco, R; Govoni, S; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51431
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