In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lympocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.

Vernole, P., Tedeschi, B., Melino, G., Pianca, C., Nicoletti, B. (1992). ENHANCED CHROMOSOMAL FRAGILITY IN NEUROBLASTOMA - CORRELATION WITH POOR PROGNOSIS. ANTICANCER RESEARCH, 12(5), 1419-1421.

ENHANCED CHROMOSOMAL FRAGILITY IN NEUROBLASTOMA - CORRELATION WITH POOR PROGNOSIS

VERNOLE, PATRIZIA;MELINO, GENNARO;
1992-01-01

Abstract

In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lympocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.
1992
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
NEUROBLASTOMA; CHROMOSOMAL FRAGILITY; COMMON FRAGILE SITES
Vernole, P., Tedeschi, B., Melino, G., Pianca, C., Nicoletti, B. (1992). ENHANCED CHROMOSOMAL FRAGILITY IN NEUROBLASTOMA - CORRELATION WITH POOR PROGNOSIS. ANTICANCER RESEARCH, 12(5), 1419-1421.
Vernole, P; Tedeschi, B; Melino, G; Pianca, C; Nicoletti, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/51178
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