Background. Reinfusion of shed blood after coronary artery bypass grafting might increase the levels of cardiac enzymes with consequent difficulties in the diagnosis of perioperative myocardial infarction. Methods. Thirty consecutive patients undergoing coronary artery bypass grafting who bled at least 400 mL within the first 4 hours after operation underwent reinfusion of shed blood. Thirty consecutive patients who were not autotransfused served as control. All patients underwent enzyme determination (total creatine kinase, MB fraction, lactate dehydrogenase, and troponin I) in the shed blood and in circulating blood preoperatively, at arrival in the intensive care unit, and 6, 24, and 48 hours after operation. Results. The shed blood contained significantly higher concentration of cardiac enzymes than the circulating blood at all time intervals (p = 0.0001). The levels of creatine kinase, its MB fraction, and lactate dehydrogenase in circulating blood were significantly elevated in patients receiving autotransfusion up to 24 hours after autotransfusion. The blood levels of troponin I were not significantly different between the two group of patients at all time points. The percent fraction of MB did not increase after autotransfusion. Conclusions. The measurement of cardiac troponin I is a useful marker for the diagnosis of perioperative myocardial infarction in patients undergoing transfusion of shed blood after coronary operation

De Paulis, R., Colagrande, L., Seddio, F., Piciche, M., De Peppo, A.P., Bassano, C., et al. (1998). Levels of troponin I and cardiac enzymes after reinfusion of shed blood in coronary operations. ANNALS OF THORACIC SURGERY, 65(6), 1617-1620.

Levels of troponin I and cardiac enzymes after reinfusion of shed blood in coronary operations

BASSANO, CARLO;CHIARIELLO, LUIGI
1998

Abstract

Background. Reinfusion of shed blood after coronary artery bypass grafting might increase the levels of cardiac enzymes with consequent difficulties in the diagnosis of perioperative myocardial infarction. Methods. Thirty consecutive patients undergoing coronary artery bypass grafting who bled at least 400 mL within the first 4 hours after operation underwent reinfusion of shed blood. Thirty consecutive patients who were not autotransfused served as control. All patients underwent enzyme determination (total creatine kinase, MB fraction, lactate dehydrogenase, and troponin I) in the shed blood and in circulating blood preoperatively, at arrival in the intensive care unit, and 6, 24, and 48 hours after operation. Results. The shed blood contained significantly higher concentration of cardiac enzymes than the circulating blood at all time intervals (p = 0.0001). The levels of creatine kinase, its MB fraction, and lactate dehydrogenase in circulating blood were significantly elevated in patients receiving autotransfusion up to 24 hours after autotransfusion. The blood levels of troponin I were not significantly different between the two group of patients at all time points. The percent fraction of MB did not increase after autotransfusion. Conclusions. The measurement of cardiac troponin I is a useful marker for the diagnosis of perioperative myocardial infarction in patients undergoing transfusion of shed blood after coronary operation
Pubblicato
Rilevanza internazionale
Lettera
Sì, ma tipo non specificato
Settore ICAR/01 - Idraulica
English
Con Impact Factor ISI
biochemical marker; creatine kinase mb; heart enzyme; lactate dehydrogenase; troponin i; adult; aged; article; bleeding; blood autotransfusion; clinical article; controlled study; coronary artery bypass graft; creatine kinase blood level; diagnostic value; female; heart infarction; human; lactate dehydrogenase blood level; male; peroperative complication; priority journal; Biological Markers; Blood Loss, Surgical; Blood Transfusion, Autologous; Coronary Artery Bypass; Creatine Kinase; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Intensive Care; Isoenzymes; L-Lactate Dehydrogenase; Male; Middle Aged; Myocardial Infarction; Myocardium; Troponin I
De Paulis, R., Colagrande, L., Seddio, F., Piciche, M., De Peppo, A.P., Bassano, C., et al. (1998). Levels of troponin I and cardiac enzymes after reinfusion of shed blood in coronary operations. ANNALS OF THORACIC SURGERY, 65(6), 1617-1620.
De Paulis, R; Colagrande, L; Seddio, F; Piciche, M; De Peppo, A; Bassano, C; Tomai, F; Chiariello, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/51156
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