Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand cross-links (ICLs) in mammalian cells. Cells from individuals with Fanconi anemia (FA) are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate.
Nakanishi, K., Cavallo, F., Perrouault, L., Giovannangeli, C., Moynahan, M., Barchi, M., et al. (2011). Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication. NATURE STRUCTURAL & MOLECULAR BIOLOGY [10.1038/nsmb.2029].
Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication.
BARCHI, MARCO;
2011-04-01
Abstract
Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand cross-links (ICLs) in mammalian cells. Cells from individuals with Fanconi anemia (FA) are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate.| File | Dimensione | Formato | |
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