Prolin-rich kinase 2 (PYK2) is a nonreceptor tyrosine kinase related to the focal ad hesion kinase (FAK) p125(FAK). PYK2 is rapidly phosphorylated on tyrosine residues in response to various stimuli, such as tumor necrosis factor-alpha JNF-alpha, changes in osmolarity, elevation in intracellular calcium concentration, angiotensin, and UV irradiation. PYK2 has ligand sequences for Src homology 2 and 3 (SH-2 and SH-3), and has binding sites for paxillin and p130(cas). Activation of PYK2 leads to modulation of ion channel function, phosphorylation of tyrosine residues, and activation of the MAP kinase signaling pathways. Immunocytochemistry shows that PYK2 is present in mouse germinal and Sertoli cells (ser). Northern blot and immunoprecipitation analysis demonstrate that, among germinal cells, PYK2 is more abundant in spermatocytes (spc) and spermatids (spt); in addition, immunofluorescence analysis clearly shows that the diffuse cytoplasmic localization of PYK2 changes in a specific cellular compartment in spt and spermatozoa. (C) 2003 Wiley-Liss, Inc.
Chieffi, P., Barchi, M., Di Agostino, S., Rossi, P., Tramontano, D., & Geremia, R. (2003). Prolin-rich tyrosine kinase 2 (PYK2) expression and localization in mouse testis. MOLECULAR REPRODUCTION AND DEVELOPMENT, 65(3), 330-335.
Tipologia: | Articolo su rivista |
Citazione: | Chieffi, P., Barchi, M., Di Agostino, S., Rossi, P., Tramontano, D., & Geremia, R. (2003). Prolin-rich tyrosine kinase 2 (PYK2) expression and localization in mouse testis. MOLECULAR REPRODUCTION AND DEVELOPMENT, 65(3), 330-335. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/10 Settore BIO/16 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/mrd.10297 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 29-mag-2003 |
Titolo: | Prolin-rich tyrosine kinase 2 (PYK2) expression and localization in mouse testis |
Autori: | |
Autori: | Chieffi, P; Barchi, M; Di Agostino, S; Rossi, P; Tramontano, D; Geremia, R |
Appare nelle tipologie: | 01 - Articolo su rivista |
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