The aim of the study was to define a therapy to be combined with an immunosuppressive drug such as cyclosporin A, in order to partially reduce the nephrotoxic and hepatotoxic effects in the treated rats. Two drugs were considered: enalapril, which is an inhibitor of the angiotensin-converting enzyme, and spironolactone, which is an antagonist of aldosterone. These two drugs interrupt the renin-angiotensinogen-angiotensin chain after this has been activated by cyclosporin A, preventing peripheral vasoconstriction and more specifically the constriction of both glomerular arterioles and hepatic vessels from occurring, thus diminishing the cyclosporin A toxicity in both liver and kidney.

Iacona, A., Rossetti, A., Filingeri, V., Orsini, D., Cesarini, A., Cervelli, V., et al. (1991). Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 17, 501-506.

Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats

FILINGERI, VINCENZINO;CERVELLI, VALERIO;ADORNO, DOMENICO;CASCIANI, CARLO UMBERTO
1991-01-01

Abstract

The aim of the study was to define a therapy to be combined with an immunosuppressive drug such as cyclosporin A, in order to partially reduce the nephrotoxic and hepatotoxic effects in the treated rats. Two drugs were considered: enalapril, which is an inhibitor of the angiotensin-converting enzyme, and spironolactone, which is an antagonist of aldosterone. These two drugs interrupt the renin-angiotensinogen-angiotensin chain after this has been activated by cyclosporin A, preventing peripheral vasoconstriction and more specifically the constriction of both glomerular arterioles and hepatic vessels from occurring, thus diminishing the cyclosporin A toxicity in both liver and kidney.
1991
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/18 - CHIRURGIA GENERALE
English
Iacona, A., Rossetti, A., Filingeri, V., Orsini, D., Cesarini, A., Cervelli, V., et al. (1991). Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 17, 501-506.
Iacona, A; Rossetti, A; Filingeri, V; Orsini, D; Cesarini, A; Cervelli, V; Adorno, D; Casciani, Cu
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50901
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