The effects of different in vivo thymosin alpha one (T-alpha-1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated T-alpha-1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with T-alpha-1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-gamma), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when T-alpha-1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.
Difrancesco, P., Pica, F., Marini, S., Favalli, C., Garaci, E. (1992). THYMOSIN ALPHA-1 RESTORES MURINE T-CELL-MEDIATED RESPONSES INHIBITED BY INVIVO COCAINE ADMINISTRATION. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 14(1), 1-9.
THYMOSIN ALPHA-1 RESTORES MURINE T-CELL-MEDIATED RESPONSES INHIBITED BY INVIVO COCAINE ADMINISTRATION
PICA, FRANCESCA;MARINI, STEFANO;FAVALLI, CARTESIO;GARACI, ENRICO
1992-01-01
Abstract
The effects of different in vivo thymosin alpha one (T-alpha-1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated T-alpha-1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with T-alpha-1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-gamma), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when T-alpha-1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
