The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.
Di Francesco, F., Pica, F., Croce, C., Tubaro, E., Favalli, C. (1990). Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 3(3), 183-189.
Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice
PICA, FRANCESCA;
1990-01-01
Abstract
The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
