The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.

Di Francesco, F., Pica, F., Croce, C., Tubaro, E., Favalli, C. (1990). Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 3(3), 183-189.

Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice

PICA, FRANCESCA;
1990-01-01

Abstract

The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.
1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
cocaine; morphine; animal cell; animal experiment; article; controlled study; cytotoxicity; immunosurveillance; intraperitoneal drug administration; mouse; natural killer cell; nonhuman
Di Francesco, F., Pica, F., Croce, C., Tubaro, E., Favalli, C. (1990). Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 3(3), 183-189.
Di Francesco, F; Pica, F; Croce, C; Tubaro, E; Favalli, C
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50857
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact