The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.

Di Francesco F., P.F. (1990). Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 3(3), 183-189.

Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice

PICA, FRANCESCA;
1990

Abstract

The ability of cocaine and morphine to influence Natural Killer (NK) cell activity in mice was examined. A dose-related inhibition in cytolytic activity was found when BALB/c mice were treated with the drugs. On the other hand, an acute intraperitoneal (i.p.) administration of cocaine (2 mg/kg) induces a very rapid (24 h) inhibition of natural cytotoxicity, with a return to normal within 72 h after treatment. By contrast, a single i.p. dose of morphine (5 mg/kg) showed a more protracted immunologic consequence (within 96 h) and a more delayed recovery (over 120 h) after suspension of the treatment. These results show that, in a dose-related manner and a different drug related reversibility, cocaine and morphine cause an inhibition on cellular cytotoxic response.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
cocaine; morphine; animal cell; animal experiment; article; controlled study; cytotoxicity; immunosurveillance; intraperitoneal drug administration; mouse; natural killer cell; nonhuman
Di Francesco F., P.F. (1990). Cocaine vs morphine: Differential inhibitory effects of natural killer cell activity in mice. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 3(3), 183-189.
Di Francesco, F; Pica, F; Croce, C; Tubaro, E; Favalli, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/50857
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