A small pool of long-lived memory CD4 T cells harboring the retroviral genome is one main obstacle to HIV eradication. We tested the impact of the gold compound, auranofin, on phenotype and viability of CD4 T cells in vitro, and on persistence of lentiviral reservoir cells in vivo.

Lewis, M., Dafonseca, S., Chomont, N., Palamara, A., Tardugno, M., Mai, A., et al. (2011). Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension, 25(11), 1347-56 [10.1097/QAD.0b013e328347bd77].

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

GARACI, ENRICO;
2011-07-17

Abstract

A small pool of long-lived memory CD4 T cells harboring the retroviral genome is one main obstacle to HIV eradication. We tested the impact of the gold compound, auranofin, on phenotype and viability of CD4 T cells in vitro, and on persistence of lentiviral reservoir cells in vivo.
17-lug-2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Treatment Outcome; DNA, Viral; Pilot Projects; Simian immunodeficiency virus; Animals; Virus Replication; Virus Latency; Antirheumatic Agents; Auranofin; Simian Acquired Immunodeficiency Syndrome; Viral Load; CD4-Positive T-Lymphocytes; Anti-Retroviral Agents; Macaca mulatta
Lewis, M., Dafonseca, S., Chomont, N., Palamara, A., Tardugno, M., Mai, A., et al. (2011). Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension, 25(11), 1347-56 [10.1097/QAD.0b013e328347bd77].
Lewis, M; Dafonseca, S; Chomont, N; Palamara, A; Tardugno, M; Mai, A; Collins, M; Wagner, W; Yalley Ogunro, J; Greenhouse, J; Chirullo, B; Norelli, S; Garaci, E; Savarino, A
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50848
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact