An experimental study on rats in order to discovery any possible interaction between Ciclosporin (CyA) and H2-receptor antagonists has been carried out. The results obtained demonstrated that the serum levels of CyA were higher in rats treated with CyA and Cimetidine or Ranitidine, but not Famotidine. It is probable that the increase of ciclosporinaemia is the consequence of an increased hepatotoxicity due to administration of Cya in association with Cimetidine or Ranitidine.
Filingeri, V., Rosati, R., Iacona, A., Giacomelli, R., Famularo, G., Calogero, A., et al. (1990). Cyclosporin (CyA) and H2 antagonists. MINERVA MEDICA, 81, 399-402.
Cyclosporin (CyA) and H2 antagonists
FILINGERI, VINCENZINO;ROSATI, ROBERTO;CERVELLI, VALERIO;CASCIANI, CARLO UMBERTO
1990-01-01
Abstract
An experimental study on rats in order to discovery any possible interaction between Ciclosporin (CyA) and H2-receptor antagonists has been carried out. The results obtained demonstrated that the serum levels of CyA were higher in rats treated with CyA and Cimetidine or Ranitidine, but not Famotidine. It is probable that the increase of ciclosporinaemia is the consequence of an increased hepatotoxicity due to administration of Cya in association with Cimetidine or Ranitidine.File in questo prodotto:
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