In a murine model of invasive pulmonary aspergillosis, dendritic cells (DCs) pulsed with Aspergillus antigens induced the activation of CD4+ Th1 cells capable of conferring resistance to the infection. Here we show that the combined, local delivery of unmethylated CpG oligodeoxynucleotides (ODNs) and the Asp f 16 Aspergillus allergen resulted in the functional maturation and activation of airway DCs capable of inducing Th1 priming and resistance to the fungus. Therefore, ODNs act as a potent adjuvant for the vaccine-induced protection against the fungus by promoting dominant Th1 response to Aspergillus antigens and allergens. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Bozza S., G.R. (2002). Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants. MICROBES AND INFECTION, 4(13), 1281-1290.
Tipologia: | Articolo su rivista |
Citazione: | Bozza S., G.R. (2002). Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants. MICROBES AND INFECTION, 4(13), 1281-1290. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S1286-4579(02)00007-2 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2002 |
Titolo: | Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants |
Autori: | |
Autori: | Bozza S., Gaziano R., Lipford G.B., Montagnoli C., Bacci A., Di Francesco P., Kurup V.P., Wagner H., Romani L. |
Appare nelle tipologie: | 01 - Articolo su rivista |