This paper shows that an acute morphine treatment dose-depently alters the energetic and oxidative metabolism of polymorphonuclear leukocytes obtained from BALB/c and DBA/2 mice, while phagocytic cells from C57BL/6 were not affected. In sensitive mouse strains, i.e. BALB/c and DBA/2, morphine decreased both ATP concentration and energy charge potential. At the same time, ATP catabolic products, i.e. nucleosides (inosine+adenosine) and oxypurines (hypoxanthine+xanthine+uric acid), significantly increased, indicating an imbalance between energy production and consumption. Morphine treatment also induced malondialdehyde and superoxide anions production in leukocyte cells from sensitive mice. The opiate antagonist naloxone blocked morphine-induced modifications by the lower morphine dose. The same parameters in cells from C57BL/6 mice were not affected. These findings confirm that: i) the phagocytic cells are an important target for the in vivo effects of morphine, and ii) the genotype-dependent variation influences the immunological responsiveness to opiates.

DI FRANCESCO, P., Tavazzi, B., Gaziano, R., Lazzarino, G., Casalinuovo, I.a., Di Pierro, D., et al. (1998). Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains. LIFE SCIENCES, 63(24), 2167-2174 [10.1016/S0024-3205(98)00497-4].

Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains

DI FRANCESCO, PAOLO;GAZIANO, ROBERTA;CASALINUOVO, IDA ANTONIA;GARACI, ENRICO
1998-01-01

Abstract

This paper shows that an acute morphine treatment dose-depently alters the energetic and oxidative metabolism of polymorphonuclear leukocytes obtained from BALB/c and DBA/2 mice, while phagocytic cells from C57BL/6 were not affected. In sensitive mouse strains, i.e. BALB/c and DBA/2, morphine decreased both ATP concentration and energy charge potential. At the same time, ATP catabolic products, i.e. nucleosides (inosine+adenosine) and oxypurines (hypoxanthine+xanthine+uric acid), significantly increased, indicating an imbalance between energy production and consumption. Morphine treatment also induced malondialdehyde and superoxide anions production in leukocyte cells from sensitive mice. The opiate antagonist naloxone blocked morphine-induced modifications by the lower morphine dose. The same parameters in cells from C57BL/6 mice were not affected. These findings confirm that: i) the phagocytic cells are an important target for the in vivo effects of morphine, and ii) the genotype-dependent variation influences the immunological responsiveness to opiates.
1998
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
morphine; energetic metabolism; oxidative metabolism; polymorphonuclear cells; neuroimmunomodulation; opioid receptors
DI FRANCESCO, P., Tavazzi, B., Gaziano, R., Lazzarino, G., Casalinuovo, I.a., Di Pierro, D., et al. (1998). Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains. LIFE SCIENCES, 63(24), 2167-2174 [10.1016/S0024-3205(98)00497-4].
DI FRANCESCO, P; Tavazzi, B; Gaziano, R; Lazzarino, G; Casalinuovo, Ia; Di Pierro, D; Garaci, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50576
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