This paper shows that morphine increases Sendai virus replication in cultured epithelial cells. The effect was maximal when it was added before viral infection. Morphine also reduced the intracellular level of glutathione, namely, the oxidative and most abundant cell thiol. Altered intracellular redox status has recently been proposed as a factor influencing viral infection. Support for this view was provided by our data showing that inhibition of de novo glutathione synthesis, using L-buthionine sulfoximine, increased virus replication. These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione.

Macchia, I., Palamara, A., Bué, C., Savini, P., Ciriolo, M.r., Gaziano, R., et al. (1999). Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 21(3), 185-93.

Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione

CIRIOLO, MARIA ROSA;GAZIANO, ROBERTA;
1999-03-01

Abstract

This paper shows that morphine increases Sendai virus replication in cultured epithelial cells. The effect was maximal when it was added before viral infection. Morphine also reduced the intracellular level of glutathione, namely, the oxidative and most abundant cell thiol. Altered intracellular redox status has recently been proposed as a factor influencing viral infection. Support for this view was provided by our data showing that inhibition of de novo glutathione synthesis, using L-buthionine sulfoximine, increased virus replication. These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione.
mar-1999
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Epithelial Cells; Respirovirus Infections; Cells, Cultured; Dogs; Chick Embryo; Animals; Antimetabolites; Virus Replication; Morphine; Analgesics, Opioid; Buthionine Sulfoximine; Glutathione; Oxidation-Reduction; Respirovirus; Kidney
Macchia, I., Palamara, A., Bué, C., Savini, P., Ciriolo, M.r., Gaziano, R., et al. (1999). Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 21(3), 185-93.
Macchia, I; Palamara, A; Bué, C; Savini, P; Ciriolo, Mr; Gaziano, R; di Francesco, P
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50449
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