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EnglishTreatment of systemic infection with Candida albicans with a combination of an antifungal agent (i.e. fluconazole) and a thymus-derived immunostimulant (i.e. thymosin alpha 1 (T alpha 1)) in mice immunosuppressed by morphine treatments was investigated. In normal mice, fluconazole given after infection with 10(6) C. albicans cells was more effective than in mice treated with morphine. Combination treatment with fluconazole and T alpha 1 prolonged survival and reduced the fungal burden in the kidneys of immunosuppressed mice. We also investigated the influence of this combined treatment on killing properties of polymorphonuclear leucocytes (PMN) and natural killer (NK) cell activity, inhibited by morphine administrations. Treatment with T alpha 1 or fluconazole as single agents promoted a recovery of normal NK cell activity and intracellular killing of C. albicans by PMN, while the combination significantly increased both of these responses, probably through the modulation of lymphokine production. Our data suggest that the additive effect of T alpha 1 and fluconazole is due to a direct antifungal action and activation of the immunocompetence.
di Francesco, P., Gaziano, R., Casalinuovo, I.A., Belogi, L., Palamara, A.T., Favalli, C., et al. (1994). Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immunosuppressed by morphine treatments. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 97(3), 347-52.
| Tipologia: | Articolo su rivista |
| Citazione: | di Francesco, P., Gaziano, R., Casalinuovo, I.A., Belogi, L., Palamara, A.T., Favalli, C., et al. (1994). Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immunosuppressed by morphine treatments. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 97(3), 347-52. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | set-1994 |
| Titolo: | Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immunosuppressed by morphine treatments |
| Autori: | |
| Autori: | di Francesco, P; Gaziano, R; Casalinuovo, IA; Belogi, L; Palamara, AT; Favalli, C; Garaci, E |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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