Brain cells express extremely different sensitivity to ischemic insults. The reason for this differential vulnerability is still largely unknown. Here we discuss the ionic bases underlying the physiological responses to in vitro ischemia in two neostriatal neuronal subtypes exhibiting respectively high sensitivity and high resistance to energy deprivation. Vulnerable neostriatal neurons respond to ischemia with a membrane depolarization. This membrane depolarization mainly depends on the increased permeability to Na+ ions. In contrast, resistant neostriatal neurons respond to ischemia with a membrane hyperpolarization due to the opening of K+ channels. Interestingly, in both neuronal subtypes the ischemia-dependent membrane potential changes can be significantly enhanced or attenuated by a variety of pharmacological agents interfering with intracellular Ca2+ entry, ATP-dependent K+ channels opening, and Na+/Ca2+ exchanger functioning. The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults.

Centonze, D., Marfia, G.a., Pisani, A., Picconi, B., Giacomini, P., Bernardi, G., et al. (2001). Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons. PROGRESS IN NEUROBIOLOGY, 63(6), 687-696 [10.1016/S0301-0082(00)00037-X].

Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons

CENTONZE, DIEGO;MARFIA, GIROLAMA ALESSANDRA;PISANI, ANTONIO;BERNARDI, GIORGIO;CALABRESI, PAOLO
2001-04-01

Abstract

Brain cells express extremely different sensitivity to ischemic insults. The reason for this differential vulnerability is still largely unknown. Here we discuss the ionic bases underlying the physiological responses to in vitro ischemia in two neostriatal neuronal subtypes exhibiting respectively high sensitivity and high resistance to energy deprivation. Vulnerable neostriatal neurons respond to ischemia with a membrane depolarization. This membrane depolarization mainly depends on the increased permeability to Na+ ions. In contrast, resistant neostriatal neurons respond to ischemia with a membrane hyperpolarization due to the opening of K+ channels. Interestingly, in both neuronal subtypes the ischemia-dependent membrane potential changes can be significantly enhanced or attenuated by a variety of pharmacological agents interfering with intracellular Ca2+ entry, ATP-dependent K+ channels opening, and Na+/Ca2+ exchanger functioning. The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults.
apr-2001
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Ion Channels; Receptors, Neurotransmitter; Cell Survival; Neurons; Neostriatum; Brain Ischemia; Animals; Neurotransmitter Agents; Humans
Centonze, D., Marfia, G.a., Pisani, A., Picconi, B., Giacomini, P., Bernardi, G., et al. (2001). Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons. PROGRESS IN NEUROBIOLOGY, 63(6), 687-696 [10.1016/S0301-0082(00)00037-X].
Centonze, D; Marfia, Ga; Pisani, A; Picconi, B; Giacomini, P; Bernardi, G; Calabresi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50319
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