The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.
Pisani, A., Bonsi, P., Centonze, D., Bernardi, G., Calabresi, P. (2001). Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons. NEUROPHARMACOLOGY, 40(3), 460-463 [10.1016/S0028-3908(00)00184-2].
Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
PISANI, ANTONIO;CENTONZE, DIEGO;BERNARDI, GIORGIO;CALABRESI, PAOLO
2001-03-01
Abstract
The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.File in questo prodotto:
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