The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.

Porfirio, B., Tedeschi, B., Vernole, P., Caporossi, D., Nicoletti, B. (1989). The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites. MUTATION RESEARCH, 213(2), 117-124.

The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites

VERNOLE, PATRIZIA;
1989-08-01

Abstract

The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.
ago-1989
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Chromosome Fragility; Chromosome Banding; Chromosome Aberrations; Chromosome Fragile Sites; Karyotyping; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; Lymphocytes; Humans
Porfirio, B., Tedeschi, B., Vernole, P., Caporossi, D., Nicoletti, B. (1989). The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites. MUTATION RESEARCH, 213(2), 117-124.
Porfirio, B; Tedeschi, B; Vernole, P; Caporossi, D; Nicoletti, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/50280
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