Background: Cytokines are the main mediators of inflammation and the response to trauma. The purpose of this study was to compare variations in cytokine levels following laparoscopic cholecystectomy (LC) and mini-laparotomy cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. Methods: A total of 40 patients were studied. Eighteen of them underwent LC; the remaining 22 were operated on using the open technique. Systemic concentrations of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor (TNF), and C-reactive protein (CRP) were measured before and after the operation. In addition, we compared pre- and postoperative white blood cell (WBC) counts, postoperative body temperature, and length of postoperative hospitalization. Results: There was no difference between the two groups in IL-1 and TNF response. The rise in plasma IL-6 levels (18.86+/-9.61 vs 5.00+/-0.0 pg/ml, p<0.0001) and CRP (8.40&PLUSMN;5.81 vs 1.43&PLUSMN;1.30 mg/dl, p<0.001) were more marked after open cholecystectomy than after the laparoscopic procedure. There was no correlation between serum CRP concentrations and the other postoperative parameters. Conclusion: The magnitude of the acute-phase response was less pronounced following laparoscopic cholecystectomy, consistent with a reduction in tissue trauma.

Grande, M., Tucci, G., Adorisio, O., Barini, A., Rulli, F., Neri, A., et al. (2002). Systemic acute-phase response after laparoscopic and open cholecystectomy. SURGICAL ENDOSCOPY, 16(2), 313-316 [10.1007/s00464-001-9042-5].

Systemic acute-phase response after laparoscopic and open cholecystectomy

GRANDE, MICHELE;TUCCI, GIANFRANCO;RULLI, FRANCESCO;NERI, ANNA;FARINON, ATTILIO MARIA;NERI, ANNA
2002

Abstract

Background: Cytokines are the main mediators of inflammation and the response to trauma. The purpose of this study was to compare variations in cytokine levels following laparoscopic cholecystectomy (LC) and mini-laparotomy cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. Methods: A total of 40 patients were studied. Eighteen of them underwent LC; the remaining 22 were operated on using the open technique. Systemic concentrations of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor (TNF), and C-reactive protein (CRP) were measured before and after the operation. In addition, we compared pre- and postoperative white blood cell (WBC) counts, postoperative body temperature, and length of postoperative hospitalization. Results: There was no difference between the two groups in IL-1 and TNF response. The rise in plasma IL-6 levels (18.86+/-9.61 vs 5.00+/-0.0 pg/ml, p<0.0001) and CRP (8.40&PLUSMN;5.81 vs 1.43&PLUSMN;1.30 mg/dl, p<0.001) were more marked after open cholecystectomy than after the laparoscopic procedure. There was no correlation between serum CRP concentrations and the other postoperative parameters. Conclusion: The magnitude of the acute-phase response was less pronounced following laparoscopic cholecystectomy, consistent with a reduction in tissue trauma.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/18 - Chirurgia Generale
English
Con Impact Factor ISI
C reactive protein; cytokine; interleukin 1; interleukin 6; tumor necrosis factor; acute phase response; adult; aged; article; blood level; body temperature; cholecystectomy; clinical article; controlled study; cytokine production; female; hospitalization; human; inflammation; laparoscopic surgery; length of stay; leukocyte count; male; postoperative period; preoperative evaluation; priority journal; surgical technique; tissue injury; Acute-Phase Reaction; Adult; C-Reactive Protein; Cholecystectomy; Female; Humans; Interleukin-1; Interleukin-6; Laparoscopy; Male; Middle Aged; Tumor Necrosis Factor-alpha
Grande, M., Tucci, G., Adorisio, O., Barini, A., Rulli, F., Neri, A., et al. (2002). Systemic acute-phase response after laparoscopic and open cholecystectomy. SURGICAL ENDOSCOPY, 16(2), 313-316 [10.1007/s00464-001-9042-5].
Grande, M; Tucci, G; Adorisio, O; Barini, A; Rulli, F; Neri, A; Franchi, F; Farinon, Am; Neri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/50117
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