Background: Cytokines are the main mediators of inflammation and the response to trauma. The purpose of this study was to compare variations in cytokine levels following laparoscopic cholecystectomy (LC) and mini-laparotomy cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. Methods: A total of 40 patients were studied. Eighteen of them underwent LC; the remaining 22 were operated on using the open technique. Systemic concentrations of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor (TNF), and C-reactive protein (CRP) were measured before and after the operation. In addition, we compared pre- and postoperative white blood cell (WBC) counts, postoperative body temperature, and length of postoperative hospitalization. Results: There was no difference between the two groups in IL-1 and TNF response. The rise in plasma IL-6 levels (18.86+/-9.61 vs 5.00+/-0.0 pg/ml, p<0.0001) and CRP (8.40&PLUSMN;5.81 vs 1.43&PLUSMN;1.30 mg/dl, p<0.001) were more marked after open cholecystectomy than after the laparoscopic procedure. There was no correlation between serum CRP concentrations and the other postoperative parameters. Conclusion: The magnitude of the acute-phase response was less pronounced following laparoscopic cholecystectomy, consistent with a reduction in tissue trauma.
Grande, M., Tucci, G.F., Adorisio, O., Barini, A., Rulli, F., Neri, A., et al. (2002). Systemic acute-phase response after laparoscopic and open cholecystectomy. SURGICAL ENDOSCOPY, 16(2), 313-316.
|Tipologia:||Articolo su rivista|
|Citazione:||Grande, M., Tucci, G.F., Adorisio, O., Barini, A., Rulli, F., Neri, A., et al. (2002). Systemic acute-phase response after laparoscopic and open cholecystectomy. SURGICAL ENDOSCOPY, 16(2), 313-316.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00464-001-9042-5|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2002|
|Titolo:||Systemic acute-phase response after laparoscopic and open cholecystectomy|
|Autori:||Grande, M; Tucci, G; Adorisio, O; Barini, A; Rulli, F; Neri, A; Franchi, F; Farinon, AM; Neri, A.|
|Appare nelle tipologie:||01 - Articolo su rivista|