We have characterized the extent and the phenotype of total and proliferating cell-population of aortic plaques in aged rabbits receiving a long-term low-dose cholesterol hyperlipemic diet, which represents an experimental model of atherosclerosis. For nine months, rabbits received the hypercholesterolemic diet alone or in addition to a treatment with propionyl-L-carnitine (PLC), a derivative of carnitine, an intramitochondrial carrier of fatty acids present in most cell types. We observed that, in both PLC-treated and control hyperlipemic rabbits, the ratio between proliferating macrophage-derived and smooth muscle cells was 2:1. PLC in addition to the hypercholesterolemic diet induced a marked lowering of plasma triglycerides, very low density lipoprotein (VLDL) and intermediate density lipoprotein (VLDL) triglycerides, while plasma cholesterol was slightly and transiently reduced. Moreover, PLC-treated hyperlipemic rabbits exhibited a reduction of plaque thickness and extent, a slight but significant reduction of the percentage of macrophage-derived cells as compared to control hyperlipemic animals and a reduction of the number of both proliferating macrophage- and smooth muscle cell-derived foam cells. Finally, both proliferating and non-proliferating plaque cells expressed large amounts of macrophage colony-stimulating factor protein, in particular macrophage-derived foam cells. These results indicate that a modification of plasma lipemic pattern obtained by a long-term oral administration of PLC was associated with a decrease of plaque cell proliferation and severity of aortic atherosclerotic lesions.
Spagnoli, L.G., Orlandi, A., Marino, B., Mauriello, A., De Angelis, C., & Ramacci, M.T. (1995). Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits. ATHEROSCLEROSIS, 114(1), 29-44.
|Tipologia:||Articolo su rivista|
|Citazione:||Spagnoli, L.G., Orlandi, A., Marino, B., Mauriello, A., De Angelis, C., & Ramacci, M.T. (1995). Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits. ATHEROSCLEROSIS, 114(1), 29-44.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0021-9150(94)05460-Z|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||1995|
|Titolo:||Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits|
|Autori:||Spagnoli, LG; Orlandi, A; Marino, B; Mauriello, A; De Angelis, C; Ramacci, MT|
|Appare nelle tipologie:||01 - Articolo su rivista|