Background: There is evidence that treatment with the 11 beta-hydroxylase inhibitor metyrapone may represent an alternative treatment strategy in major depression, As a consequence of inhibition of cortisol synthesis the overdrive of corticotropin leads to an accumulation of precursor steroids. However, the effects of metyrapone on the concentrations of endogenous neuroactive steroids that modulate ion channels, e.g., the GABA(A) receptor, have not vet been studied systematically. Methods: Therefore, we quantified the concentrations of an array of neuroactive steroids following administration of 1.5g metyrapone before and after pretreatment with I mg dexamethasone in 19 patients suffering from severe depression in comparison to 13 healthy controls by means of a highly sensitive gas chromatography/mass spectrometry analysis. Results: The administration of metyrapone induced a pronouced increase in all neuroactive steroids studied both in patients and controls that was prevented by dexamethasone pretreatment. Conclusions: Thus, the psychotropic properties of endogenous neuroactive steroids may contribute to the antidepressant propel-ties of metyrapone in the treatment of major depression, (C) 1998 Society of Biological Psychiatry.
Rupprecht R., S.A. (1998). Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers. BIOLOGICAL PSYCHIATRY, 44(9), 912-914.
|Tipologia:||Articolo su rivista|
|Citazione:||Rupprecht R., S.A. (1998). Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers. BIOLOGICAL PSYCHIATRY, 44(9), 912-914.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore BIO/09|
Settore MED/39 - Neuropsichiatria Infantile
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0006-3223(97)00521-0|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||1998|
|Titolo:||Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers|
|Autori:||Rupprecht R., Strohle A., Hermann B., Di Michele F., Spalletta G., Pasini A., Holsboer F., Romeo E.|
|Appare nelle tipologie:||01 - Articolo su rivista|