A 52-year-old Caucasian man treated with granulocyte-macrophage colonystimulating factor (GM- CSF) developed a cutaneous eruption on legs and ankles with clinical and histologic features of erythema multiforme. Laboratory studies indicated that the eruption occured at the time of peripheral blood lymphocyte recovery and that it was coincidental with serum peaks of interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumour necrosis factor-alpha. We postulate that GM-CSF provoked erythema multiforme in a predisposed individual as a consequence of either an inappropriate cytokine secretion or of an abnormal amplification mechanism following lympocyte recovery.

Stasi, R., Gatti, S., Perrotti, A., Orlandi, A., Spagnoli, L.g., Papa, G. (1994). ERYTHEMA MULTIFORME DURING GM-CSF THERAPY. ACTA DERMATO-VENEREOLOGICA, 74(2), 132-134.

ERYTHEMA MULTIFORME DURING GM-CSF THERAPY

ORLANDI, AUGUSTO;SPAGNOLI, LUIGI GIUSTO;
1994-01-01

Abstract

A 52-year-old Caucasian man treated with granulocyte-macrophage colonystimulating factor (GM- CSF) developed a cutaneous eruption on legs and ankles with clinical and histologic features of erythema multiforme. Laboratory studies indicated that the eruption occured at the time of peripheral blood lymphocyte recovery and that it was coincidental with serum peaks of interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6) and tumour necrosis factor-alpha. We postulate that GM-CSF provoked erythema multiforme in a predisposed individual as a consequence of either an inappropriate cytokine secretion or of an abnormal amplification mechanism following lympocyte recovery.
1994
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Con Impact Factor ISI
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; NON-HODGKINS LYMPHOMA; CYTOKINES
3
Stasi, R., Gatti, S., Perrotti, A., Orlandi, A., Spagnoli, L.g., Papa, G. (1994). ERYTHEMA MULTIFORME DURING GM-CSF THERAPY. ACTA DERMATO-VENEREOLOGICA, 74(2), 132-134.
Stasi, R; Gatti, S; Perrotti, A; Orlandi, A; Spagnoli, Lg; Papa, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49944
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