Patients affected by some genetic skin defects, for example, dyskeratosis congenita or scleroderma, may present spontaneous or induced chromosomal fragility. Hence we performed a cytogenetic analysis in families of patients affected by lamellar ichthyosis, an autosomal recessive disease not yet fully characterized at the cellular and molecular levels. Chromosomal fragility was assayed in untreated lymphocyte cultures and in those supplemented with aphidicolin or bleomycin. Cells from some affected patients and some of their parents showed hypersensitivity to the radiomimetic agent bleomycin. (C) Elsevier Science Inc., 1998.
Vernole P., T.A. (1999). Bleomycin-induced chromosome aberrations in lymphocytes derived from patients with lamellar ichthyosis. CANCER GENETICS AND CYTOGENETICS, 108(2), 154-157.
Tipologia: | Articolo su rivista |
Citazione: | Vernole P., T.A. (1999). Bleomycin-induced chromosome aberrations in lymphocytes derived from patients with lamellar ichthyosis. CANCER GENETICS AND CYTOGENETICS, 108(2), 154-157. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/13 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0165-4608(98)00136-8 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1999 |
Titolo: | Bleomycin-induced chromosome aberrations in lymphocytes derived from patients with lamellar ichthyosis |
Autori: | |
Autori: | Vernole P., Tullio A., Caporossi D., Didona B., Melino G., Tedeschi B. |
Appare nelle tipologie: | 01 - Articolo su rivista |