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EnglishRestriction endonucleases have been shown to induce chromosome damage in a variety of cultured cells. We recently reported the coincidence between MspI-induced breakage and the location of common fragile sites. We have extended our study to HpaII, which induced a 4.5-fold increase in total breakage compared to controls. It appeared that a major contribution was given by stable chromosome rearrangements, which were present at a 14-fold increased frequency in comparison to the spontaneous levels. Moreover, several chromosome bands were involved in rearrangements in different cultures from different donors. Notably, HpaII-induced breakage occurred in the same bands where breakpoints of constitutional and neoplastic rearrengements are located.
Tedeschi B., P.B. (1991). Structural chromosomal rearrangements in HpaII-treated human lymphocytes, 248(1), 115-121.
| Tipologia: | Articolo su rivista | |
| Citazione: | Tedeschi B., P.B. (1991). Structural chromosomal rearrangements in HpaII-treated human lymphocytes, 248(1), 115-121. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/13 | |
| Revisione (peer review): | Sì, ma tipo non specificato | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0027-5107(91)90093-4 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 1991 | |
| Titolo: | Structural chromosomal rearrangements in HpaII-treated human lymphocytes | |
| Autori: | ||
| Autori: | Tedeschi B., Porfirio B., Caporossi D., Vernole P., Nicoletti B. | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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http://hdl.handle.net/2108/49923
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