The relationship between the spatial location of limb and the activity of cerebellar neurons has received little attention and its nature still remains ambiguous. To address this question we studied the activity of Purkinje and nucleus interpositus cells in relation to the spatial location of rat forelimb. A computer-controlled robot arm displaced the limb passively across 15 positions distributed on a parasagittal plane. The limb was upheld for 8 s in each position, which was identified by the Cartesian coordinates of the forepaw. We selected the neurons whose activities were significantly modulated by forepaw position and found that the majority represented preferentially one spatial dimension of the Cartesian plane both in the cerebellar cortex and nucleus interpositus. In particular, the antero-posterior axis was best represented in cerebellar neuronal discharges. This result suggests that the intermediate part of the cerebellum might encode limb position by way of an anisotropic representation of the spatial coordinates of the limb end-point. (C) 2003 Elsevier Science B.V. All rights reserved.

Casabona, A., Valle, M.S., Bosco, G., Garifoli, A., Lombardo, S.A., & Perciavalle, V. (2003). Anisotropic representation of forelimb position in the cerebellar cortex and nucleus interpositus of the rat. BRAIN RESEARCH [10.1016/S0006-8993(03)02513-7].

Anisotropic representation of forelimb position in the cerebellar cortex and nucleus interpositus of the rat

BOSCO, GIANFRANCO;
2003

Abstract

The relationship between the spatial location of limb and the activity of cerebellar neurons has received little attention and its nature still remains ambiguous. To address this question we studied the activity of Purkinje and nucleus interpositus cells in relation to the spatial location of rat forelimb. A computer-controlled robot arm displaced the limb passively across 15 positions distributed on a parasagittal plane. The limb was upheld for 8 s in each position, which was identified by the Cartesian coordinates of the forepaw. We selected the neurons whose activities were significantly modulated by forepaw position and found that the majority represented preferentially one spatial dimension of the Cartesian plane both in the cerebellar cortex and nucleus interpositus. In particular, the antero-posterior axis was best represented in cerebellar neuronal discharges. This result suggests that the intermediate part of the cerebellum might encode limb position by way of an anisotropic representation of the spatial coordinates of the limb end-point. (C) 2003 Elsevier Science B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09
English
PRIMARY SOMATOSENSORY CORTEX; ARM REACHING MOVEMENTS; SIMPLE SPIKE DISCHARGE; 2 MAINTAINED POSTURES; SPINOCEREBELLAR ACTIVITY; PROMPT MOVEMENTS; SENSORY INPUT; LIMB MOVEMENT; CELL OUTPUT; MONKEY
Casabona, A., Valle, M.S., Bosco, G., Garifoli, A., Lombardo, S.A., & Perciavalle, V. (2003). Anisotropic representation of forelimb position in the cerebellar cortex and nucleus interpositus of the rat. BRAIN RESEARCH [10.1016/S0006-8993(03)02513-7].
Casabona, A; Valle, M; Bosco, G; Garifoli, A; Lombardo, S; Perciavalle, V
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/49814
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