Radiolabelled cytokines and chemokines are a new group of radiopharmaceuticals. These, by binding to specific receptors expressed on selected cell populations, enable the histological and functional characterization of immune-mediated processes, in vivo. Clinical studies have demonstrated the efficacy of using this type of scintigraphy in detecting sites of acute inflammation (infection) and chronic (T-cell-mediated) inflammation. Recent studies are focusing on the possible use of radiolabelled cytokines and chemokines for the biological characterization of cancer cells in vivo. In particular, the homing of metastases into specific tissues could depend on the chemoattraction of these tissues, mediated by soluble chemokines that bind to specific receptors expressed on cancer cells. These studies will generate a deeper knowledge of the molecular mechanism of tumor metastasis and lead to new therapies in nuclear medicine.

Signore, A., Capriotti, G., Scopinaro, F., Bonanno, E., Modesti, A. (2003). Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer. TRENDS IN IMMUNOLOGY, 24(7), 395-402 [10.1016/S1471-4906(03)00174-1].

Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer

BONANNO, ELENA;MODESTI, ANDREA
2003-01-01

Abstract

Radiolabelled cytokines and chemokines are a new group of radiopharmaceuticals. These, by binding to specific receptors expressed on selected cell populations, enable the histological and functional characterization of immune-mediated processes, in vivo. Clinical studies have demonstrated the efficacy of using this type of scintigraphy in detecting sites of acute inflammation (infection) and chronic (T-cell-mediated) inflammation. Recent studies are focusing on the possible use of radiolabelled cytokines and chemokines for the biological characterization of cancer cells in vivo. In particular, the homing of metastases into specific tissues could depend on the chemoattraction of these tissues, mediated by soluble chemokines that bind to specific receptors expressed on cancer cells. These studies will generate a deeper knowledge of the molecular mechanism of tumor metastasis and lead to new therapies in nuclear medicine.
2003
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE
English
Con Impact Factor ISI
chemokine; cytokine; epidermal growth factor; gamma interferon; growth factor; indium 111; interleukin 1; interleukin 1 receptor blocking agent; interleukin 12; interleukin 2; interleukin 3; interleukin 6; interleukin 8; iodine 123; iodine 125; iodine 131; lymphokine; macrophage inflammatory protein 1alpha; monocyte chemotactic protein 1; monocyte chemotactic protein 3; RANTES; stromal cell derived factor 1alpha; technetium 99m; transforming growth factor beta; vasculotropin; acute disease; binding affinity; cancer cell; cancer localization; cell activity; cell population; chronic disease; diagnostic imaging; disease activity; follow up; functional assessment; histopathology; human; image analysis; immune response; in vivo study; infection; inflammation; isotope labeling; malignant neoplastic disease; metastasis; molecular mechanics; nonhuman; pathological anatomy; pathophysiology; patient selection; prognosis; protein binding; protein expression; receptor binding; review; scintigraphy; T lymphocyte; target cell; treatment indication; Breast Neoplasms; Chemokines; Cytokines; Female; Growth Substances; Humans; Infection; Inflammation; Lymphokines; Neoplasms; Radiopharmaceuticals
Signore, A., Capriotti, G., Scopinaro, F., Bonanno, E., Modesti, A. (2003). Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer. TRENDS IN IMMUNOLOGY, 24(7), 395-402 [10.1016/S1471-4906(03)00174-1].
Signore, A; Capriotti, G; Scopinaro, F; Bonanno, E; Modesti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49721
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