Despite the fact that the horse is one of the more common domesticated animals, there are few reports dealing with the properties of its blood, and no comprehensive study has been performed on the reactivity of horse haemoglobin towards organic and inorganic ions. Here we report data on the effects of the organic phosphates D-glycerate-2,3-bisphosphate (2,3-DPG) and InsP6, and of chloride on the properties of horse haemoglobin. Thus the effect of saturating concentrations of 2,3-DPG on the oxygen affinity of horse haemoglobin is about 60% lower than with human adult haemoglobn under the same experimental conditions. The same applies also to InsP6, whose effect on oxygen binding to horse haemoglobin appears to be much less sensitive to organic phosphates than previously believed. These results are discussed in the light of the primary structure of the molecule.

Giardina, B., Brix, O., Clementi, M.e., Scatena, R., Nicoletti, B., Cicchetti, R., et al. (1990). Differences between horse and human haemoglobins in effects of organic and inorganic anions on oxygen binding. BIOCHEMICAL JOURNAL, 266(3), 897-900.

Differences between horse and human haemoglobins in effects of organic and inorganic anions on oxygen binding

CICCHETTI, ROSADELE;
1990-01-01

Abstract

Despite the fact that the horse is one of the more common domesticated animals, there are few reports dealing with the properties of its blood, and no comprehensive study has been performed on the reactivity of horse haemoglobin towards organic and inorganic ions. Here we report data on the effects of the organic phosphates D-glycerate-2,3-bisphosphate (2,3-DPG) and InsP6, and of chloride on the properties of horse haemoglobin. Thus the effect of saturating concentrations of 2,3-DPG on the oxygen affinity of horse haemoglobin is about 60% lower than with human adult haemoglobn under the same experimental conditions. The same applies also to InsP6, whose effect on oxygen binding to horse haemoglobin appears to be much less sensitive to organic phosphates than previously believed. These results are discussed in the light of the primary structure of the molecule.
1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
2,3 diphosphoglyceric acid; hemoglobin; animal cell; article; binding affinity; human; human cell; nonhuman; oxygen affinity; oxygen binding; priority journal; 2,3-Diphosphoglycerate; Amino Acid Sequence; Animal; Chlorides; Comparative Study; Diphosphoglyceric Acids; Hemoglobins; Horses; Human; Molecular Sequence Data; Oxygen; Animalia; Equus caballus
Giardina, B., Brix, O., Clementi, M.e., Scatena, R., Nicoletti, B., Cicchetti, R., et al. (1990). Differences between horse and human haemoglobins in effects of organic and inorganic anions on oxygen binding. BIOCHEMICAL JOURNAL, 266(3), 897-900.
Giardina, B; Brix, O; Clementi, Me; Scatena, R; Nicoletti, B; Cicchetti, R; Argentin, G; Condo, Sg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49631
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