In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo. © 2001 Lippincott Williams & Wilkins.

Macchi, B., Matteucci, C., Nocentini, U., Tacconi, S., Pagnini, V., Mastino, A., et al. (2001). Defective Fas ligand production in lymphocytes from MS patients. NEUROREPORT, 12,0(18,0), 4113,0-4116,0.

Defective Fas ligand production in lymphocytes from MS patients

MACCHI, BEATRICE;MATTEUCCI, CLAUDIA;NOCENTINI, UGO;CALTAGIRONE, CARLO
2001-01-01

Abstract

In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo. © 2001 Lippincott Williams & Wilkins.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14
English
Con Impact Factor ISI
Apoptosis; EDSS; Fas ligand; Lymphocytes; Multiple sclerosis
Macchi, B., Matteucci, C., Nocentini, U., Tacconi, S., Pagnini, V., Mastino, A., et al. (2001). Defective Fas ligand production in lymphocytes from MS patients. NEUROREPORT, 12,0(18,0), 4113,0-4116,0.
Macchi, B; Matteucci, C; Nocentini, U; Tacconi, S; Pagnini, V; Mastino, A; Caltagirone, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49569
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